Fixed-Dose Combination Drugs

Case study
Fixed-dose combination

Two cases. First, a large, multinational pharmaceutical company was seeking a CDMO partner with the expertise and technological capabilities to combine three drug substances into a fixed dose combination (FDC) product suitable for adult and pediatric dosing. The incompatibility of one of the APIs with the other two and the need for flexible dosing for a diverse patient population were key challenges. These were overcome using a combination of multi-layer tablets for adults, mini-tablets for pediatric patients, and polymer coating technologies.

Second, two drug substances with different release profiles was to be administered as one FDC drug. Here, microparticulate technology was used to meet the customer’s needs.

Read the full case study to learn how both companies were able to benefit from Cambrex’s extensive range of equipment and technological expertise, allowing them to design and develop FDC strategies that met their needs.

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